- Listed as impaired in 1996 on the State's 303(d) Impaired Water's List due to elevated levels of fecal coliform bacteria
- Subsequently listed on the 1998 list and thus fell under the 1999 Consent Decree requiring Virginia to develop TMDLs for all of the impaired stream segments listed on the 1998 303(d) Impaired Waters List by 2010
During 2001 and 2002 NVRC and DEQ developed the Fecal Coliform TMDL for Four Mile Run approved by the US Environmental Protection Agency (EPA) in May 2002.